STORY AT-A-GLANCE
- Using the PULS cardiac test, researchers have found Pfizer and Moderna mRNA COVID shots dramatically increase biomarkers associated with thrombosis, cardiomyopathy and other vascular events following vaccination
- Pre- and post-injection PULS tests for 566 patients were compared. On average, their PULS scores went from an 11% five-year risk for acute coronary syndrome, to a more than double, 25%, five-year risk
- Those who got the injection for fear that COVID-19 might adversely affect their heart now face the grim reality that they’ve exchanged a potential risk for a more certain one
- Another paper details how the mRNA shot can cause thrombocytopenia (low platelet count) through a mechanism that involves the activation of platelets by antibodies against the spike protein (anti-spike antibodies)
- A mystery that remains to be solved is why only certain people with antibodies to the spike protein (anti-spike antibodies) go on to develop symptoms of platelet activation and thrombocytopenia. One hypothesis is that only a subset of the anti-spike antibodies formed after vaccination can activate platelets and cause thrombocytopenia
In a November 21, 2021, tweet, cardiologist Dr. Aseem Malhotra writes:1
“Extraordinary, disturbing, upsetting. We now have evidence of a plausible biological mechanism of how mRNA vaccine may be contributing to increased cardiac events. The abstract is published in the highest impact cardiology journal so we must take these findings very seriously.”
The abstract he’s talking about is “mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: A Warning,” published in the November 16, 2021, issue of the journal Circulation.2 (ACS is Acute Coronary Syndrome).
“The score has been measured every 3-6 months in our patient population for 8 years. Recently, with the advent of the mRNA COVID 19 vaccines (vac) by Moderna and Pfizer, dramatic changes in the PULS score became apparent in most patients. This report summarizes those results.
A total of 566 [patients], aged 28 to 97, M:F ratio 1:1 seen in a preventive cardiology practice had a new PULS test drawn from 2 to 10 weeks following the 2nd COVID shot and was compared to the previous PULS score drawn 3 to 5 months previously pre- shot.
Baseline IL-16 increased from 35=/-20 above the norm to 82 =/- 75 above the norm post-vac; sFas increased from 22+/- 15 above the norm to 46=/-24 above the norm post-vac; HGF increased from 42+/-12 above the norm to 86+/-31 above the norm post-vac.
These changes resulted in an increase of the PULS score from 11% 5-year ACS risk to 25% 5-year ACS risk. At the time of this report, these changes persist for at least 2.5 months post second dose of vac.
We conclude that the mRNA vacs dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.”
As noted by Malhotra, this is indeed extraordinarily disturbing. Patients who received a two-dose regimen of mRNA more than doubled their five-year ACS risk, driving it from an average of 11% to 25%. Just imagine the shape our medical system and society at large will be in if 1 of every 4 people who got the two-dose regimen ends up with acute heart failure.
According to the authors, identifying the mechanism by which the shots cause thrombocytopenia would facilitate the development of a diagnostic test. Historically, heparin-induced thrombocytopenia has been diagnosed using a serotonin release assay (SRA).
Using SRA, a subset of critically ill COVID-19 patients have tested positive for platelet-activating immune complexes that can cause thrombosis. Other researchers have also showed IgG antibodies from critically ill COVID-19 patients can activate platelets, resulting in a thrombotic event.
Here, using a modified SRA, they discovered spike-dependent, platelet-activating immune complexes in a patient with vaccine-induced thrombocytopenia, suggesting the spike protein is the causative factor. They explain:10
“Our patient was a 25-year-old woman who presented to hospital 10 days after receiving the Moderna mRNA COVID-19 vaccine with fatigue, petechiae and wet purpura. The initial platelet count was 1,000 per cubic millimeter without evidence of schistocytes on blood smear.
Coagulation studies were within the normal range … This also likely excludes the presence of a lupus anticoagulant, given the use of a lupus-sensitive reagent for PTT testing. Anti-platelet factor 4 (PF4)/heparin antibodies were not detected … and the classic SRA test, with or without heparin or exogenous PF4, was negative.
Assays for drug-induced immune thrombocytopenia with washed donor platelets were also negative for platelet binding with vaccine, PEG2000, or SARS-CoV-2 Spike protein … The patient was treated with dexamethasone and intravenous immune globulin (IVIg) for a presumed immune thrombocytopenic purpura. The platelet count normalized by day seven of treatment.
Additional serum testing identified SARS-CoV-2 Spike protein antibodies of the IgG … IgA … and IgM … classes. Antibodies against SARS-CoV-2 nucleocapsid protein were absent, confirming vaccine-induced antibodies without prior infection.
To further investigate the mechanism of thrombocytopenia, we tested the patient’s serum using a modified SRA with addition of recombinant SARS-CoV-2 Spike protein (Spike-SRA). We observed dose-dependent platelet activation with increasing SARS-CoV-2 Spike protein …
The reaction was inhibited by an FcγRIIa blocker … and IVIg … confirming FcγRIIa-dependent platelet activation. Platelet activation was also demonstrated to a lesser degree with increasing amounts of Moderna vaccine … and the excipient PEG2000 …
Furthermore, platelet activation was not detected in a control sample from a patient who had received the Moderna vaccine and had not developed thrombocytopenia …
Circulating Spike protein was detected in our patient’s serum using enzyme immunoassay testing … Together, these results suggest that the thrombocytopenia in this patient was secondary to FcγRIIa-mediated platelet activation by SARS-CoV-2 Spike immune complexes.”
Platelets are specialized cells that stop bleeding, and they have ACE2 receptors, which is what the SARS-CoV-2 spike protein binds to. When the spike protein binds to the ACE2 receptor on the platelets, it activates them.
This platelet activation can lead to disseminated intravascular coagulation, i.e., a pathological overstimulation of your coagulation system that can result in abnormal, and life threatening, blood clotting, as well as thrombocytopenia (low platelet count) and hemorrhaging.
Doctors for COVID Ethics described this mechanism in a February 28, 2021, letter11 to the European Medicines Agency (EMA). In that letter, they warned that, based on this mechanism, spike protein-based COVID shots are likely to cause blood clots, cerebral vein thrombosis and sudden death, which is precisely what we’ve been seeing ever since.
In essence, you basically end up with so many blood clots throughout your vascular system that your coagulation system is exhausted, hence the low platelet count. The low platelet count, in turn, is what allows for hemorrhaging (abnormal bleeding).
The adverse changes caused by the shots persist for at least 2.5 months. That’s the low end. We still do not know what the upper time limit is. It could be a year or more, and the risks certainly do not diminish with subsequent additional doses. In the November 12, 2021, OpenVAERS report,13 they added a graph showing vaccination rates and VAERS reports by state.
As you can see, there’s a clear correlation between the rate of “fully vaccinated” in a given state and the number of COVID injuries reported from that state. (Indiana, for some reason, sticks out as a lone exception with a disproportionately high number of reports to the number of fully “vaccinated.”)
The gray zones are population; blue bars are the number of fully vaccinated; the red bars are the number of reported injuries. (All numbers have been divided by 1,000.) This is yet another piece of evidence that we have a serious problem on our hands.
