February 13, 2023

That was the title of a song about heroin by Neil Young 50 years ago. It is also the grim reality facing those who took the vaccine route in the hope of averting a COVID infection.

It turned out that the vaccination for COVID didn’t stop infection, hospitalization, or death.

The joy of vaccination has dropped off to the extent that some of the vaccination enthusiasts have asked for an amnesty for their crimes against humanity. But the damage has been done.

It was easy enough to predict that vaccination would be useless against a coronavirus. Coronaviruses simply mutate too fast. The surprise was that the COVID vaccination was worse than useless. The more doses you have, the more likely you are to be infected and re-infected.

This is a graph from one study published by medRxiv, a group founded by Yale University, Cold Spring Harbor Laboratory, and BMJ, which pre-publishes upcoming medical information ahead of its peer-review process. 

Image credit: medRxiv, shareable chart

The horizontal axis is the number of days since the start of the study. The vertical axis is the cumulative number of COVID infections by vaccination status. The black line at the bottom is the unvaccinated cohort. The orange (or tan) line at the top shows those who have had four doses. The four-dose enthusiasts have three times the infection rate of the unvaccinated. The chart can also be viewed here.

Vaccination is not supposed to increase the infection rate for a disease.

A German paper from late last year, published in Science Immunology, now tells us why.

Briefly, there are four type of Immunoglobulin G which together represent 75% of the serum antibodies in humans. IgG1, IgG2, IgG3 normally constitute 99.96% of the Immunoglobulin G in circulation. IgG4 is normally the balance of 0.04%.

What the German study found was that vaccination caused the proportion of IgG4 to rise after the second dose and again after the third dose to near 40% in some individuals after the third dose. Why this is a bad thing is because the role of IgG4 is to stop the immune system from overreacting to allergens like pollen. What that means in COVID is that the IgG4 antibodies will bind to the COVID virions and stop the rest of the immune system from attacking them. Which in turn means a higher COVID infection rate and a higher death rate.  After the third dose, those with higher IgG4 levels were more likely to be infected with COVID:

Image credit: Science Immunology, from shareable article