The True Story of the Cancer-Causing Monkey Virus and the Polio Vaccine

In 1955, Debbie Bookchin and Jim Schumacher authored the book ‘The Virus and The Vaccine : The True Story of a Cancer-Causing Monkey Virus, Contaminated Polio Vaccine, and the Millions of Americans Exposed’.  In 2004, Tom Curtis wrote an article using the book as a basis.  His article was published in The Lancet.

The cancer-causing monkey virus that was the subject of the book is Simian Virus 40 (“SV40”). We are republishing Curtis’ article as the subject of SV40 has once again become an issue in vaccines and his article is as relevant today as it was all those decades ago.

In April, microbiologist Kevin McKernan pioneered research on testing some of the covid vaccine vials and discovered unacceptable levels of double-stranded DNA plasmids floating around.  This has since been dubbed Plamisdgate.

In Pfizer’s mRNA injection, McKernan also discovered SV40 promoters which are tied to cancer development in humans. He emphasised that the SV40 found is a viral piece, it is not the whole virus.  However, it still presents a risk of driving cancer.

Last week McKernan tweeted that further tests suggested that there were billions of copies of the SV40 enhancer per dose:

Further reading: DNA fragments detected in monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: Exploratory dose response relationship with serious adverse events, Anandamide (aka Kevin McKernan), 20 October 2023

On the same day as McKernan’s tweet, Health Canada confirmed the presence of DNA contamination in Pfizer covid injections and also confirmed that Pfizer did not disclose the contamination to the public health authority.  “The DNA contamination includes the Simian Virus 40 (“SV40”) promoter and enhancer Pfizer did not previously disclose and that some experts say is a cancer risk due to potential integration with the human genome,” The Defender reported.

Janci Lindsay, PhD, director of toxicology and molecular biology for Toxicology Support Services, told The Defender that multiple sequences of SV40 were identified, including “the SV40 origin of replication, the SV40 promoter and the SV40 enhancer, which contains a nuclear targeting sequence which takes the DNA payload straight to the nucleus.”

When it was discovered many decades ago that SV40 was an animal carcinogen that had found its way into the polio vaccines, a federal law was passed in the US in 1961 that required that no vaccines contain this virus. But here we are.  In 2023, SV40 has been found in Pfizer’s covid injections.

Below we have republished the 2004 article published by The Lancet and written by Curtis that tells the story of SV40. An article we previously published on what the 1950s propaganda about Salk’s polio vaccine did and didn’t say is relevant to the article below as it includes a documentary promoting the vaccine at the time.

Monkeys, viruses, and vaccines

By Tom Curtis, 31 July 2004

On any list of medical triumphs of the 20th century, polio vaccination is sure to rate a mention. In the 1950s and early 1960s, the shot and sugar-cube vaccines of Jonas Salk, and later Albert Sabin, offered people the first opportunities to protect themselves from a scourge as feared in its day as AIDS is in our own.

Few back then grasped that these vaccines might also be a huge, inadvertent, uncontrolled experiment in interspecies viral transmission. But from 1955 to 1963, according to a 1976 US National Institutes of Health (“NIH”)-funded study, 98 million Americans alone probably were exposed to polio vaccines contaminated with SV40 – a monkey virus that can cause cancers in animals. Now, a 7July report in New Scientist has raised fears that hundreds of millions of eastern Europeans, Asians, and Africans also may have been exposed to SV40 in Soviet-made polio vaccines. Michele Carbone of Loyola University Medical Centre, Chicago, USA, announced at the 2004 Vaccine Cell Substrates meeting (Rockville, MD) that the Soviet vaccine could have been contaminated until the 1980s. This is worrying since, despite 44 years of medical debate, epidemiological studies have yet to establish conclusively whether SV40 has or hasn’t caused cancers in people.

When Salk developed his vaccine, instead of using human tissues, as did the scientists who won a Nobel Prize for first growing poliovirus in tissue culture, he used minced-up rhesus macaque monkey kidneys, which were remarkably efficient poliovirus factories. Those who sought to supplant Salk’s formaldehyde-inactivated vaccine with live, attenuated oral vaccine also used monkey kidney cultures. Despite a manufacturing problem that, at best, left six children who received the vaccine paralysed in the arm, and despite concerns about wild simian viruses, Salk’s shots were declared safe and effective after 1954 field trials. The next year, after grudging approval by sceptical government regulators, free Salk shots were made available throughout the USA.

By 1960, scientists and vaccine manufacturers knew that monkey kidneys were sewers of simian viruses. Such contamination often spoiled cultures, including those of an NIH researcher named Bernice Eddy, who worked on vaccine safety. In 1959, fresh from co-reporting that the mouse polyoma virus could cause cancer in other animals, Eddy tested the rhesus monkey kidney substrate used to make polio vaccine. She injected 154 newborn hamsters with extracts of the cell cultures: 109 developed tumours. Next, she ground up three of the tumours and injected the residue into other hamsters. The animals receiving injections from two of the three tumours developed cancers. But when Eddy put the substance back into the monkey cell culture, nothing happened, and she couldn’t isolate the suspected virus.

In The Virus and the Vaccine: The True Story of a Cancer-Causing Monkey Virus, Contaminated Polio Vaccine, and the Millions of Americans Exposed, Debbie Bookchin and Jim Schumacher report that in 1960, when Eddy presented her results to her boss, a polio vaccine champion named Joe Smadel, he was livid and disbelieving: “Its implications – that something in the polio vaccine could cause cancer – was an affront to his career.” Her discovery also threatened one of the USA’s most important public health programmes. “By 1960, tens of millions of Americans had been vaccinated against polio, and it was federal health policy that everyone should be vaccinated and continue to receive Salk booster shots.”

Eddy tried to get word out to colleagues but was muzzled and stripped of her vaccine regulatory duties and her laboratory. However, two Merck researchers, Ben Sweet and Maurice Hilleman, soon identified the rhesus virus later named SV40 – the carcinogenic agent that had eluded Eddy. In 1963, US authorities decided to switch to African green monkeys, which are not natural hosts of SV40, to produce polio vaccine. In the mid-1970s, after limited epidemiological studies, authorities concluded that although SV40 caused cancer in hamsters, it didn’t seem to do so in people.

Fast forward to the 1990s: Michele Carbone, then at NIH, was working on how SV40 induces cancers in animals. One of these was mesothelioma, a rare cancer of the pleura thought in people to be caused mainly by asbestos. The orthodoxy held that SV40 didn’t cause human cancers. Emboldened by a 1992 NEJM paper that found DNA “footprints” of SV40 in childhood brain tumours, Carbone tested human mesothelioma tumour biopsies at the National Cancer Institute: 60% contained SV40 DNA. In most, the monkey virus was active and producing proteins.

He published his results in Oncogene in May 1994, but the NIH declined to publicise them. Doubters at NIH developed epidemiological evidence that showed no correlation between people who received potentially contaminated polio vaccines and increased cancer rates. Others suggested that the SV40 DNA was a laboratory contaminant. On the first point, the US Institute of Medicine reviewed all published epidemiological studies of SV40 and found them inconclusive. Meanwhile, Carbone had moved to Loyola University. There he discovered how SV40 disables tumour suppressor genes in human mesothelioma, and published his results in Nature Medicine in July 1997. Studies in Italy, Germany, and the USA also showed associations between SV40 and human cancers.

Between 1997 and early 2003, say Bookchin and Schumacher, more than 25 published studies found SV40 in human mesotheliomas; 16 others found the virus in brain and bone cancers, lymphomas, and other cancers and in kidneys and peripheral blood. As of 2003, SV40 had been found in human tumours in 18 developed countries. Bookchin and Schumacher claim that the rates of SV40-positive tumours seem highest in countries that used the greatest amount of contaminated Salk polio vaccine, including the UK, USA, and Italy.

As the SV40 story illustrates, until scientists know that a virus exists in cell cultures, they can’t create a test to detect it and thus can’t eliminate it from vaccines grown on those cultures. Might other potentially dangerous simian viruses lurk in primary monkey kidney cultures used for polio vaccines? Such concerns were relieved in January 2000, when attenuated oral polio vaccine made since the 1950s by Lederle Laboratories on primary monkey kidney cultures was removed from the US market. Since wild-type polio cases had been eradicated in the USA in the mid-1970s, the eight to ten cases of paralysis caused yearly by return to neurovirulence of the live vaccine virus were finally deemed no longer acceptable. The vaccine was replaced with Aventis Pasteur’s killed polio vaccine grown on a well-characterised VERO monkey cell line. Thus, the odds of further contamination by unrecognised viruses are thought to have been greatly reduced.

Bookchin and Schumacher complain that since the era of Bernice Eddy the NIH hierarchy has been consistently dismissive of evidence that SV40 from vaccines may have caused human cancers. Officials who had previously said SV40 was harmless were authorised to assess independent research that challenged that conclusion: “Not surprisingly, they reaffirmed their own previous wisdom.” Accepting that SV40 is a human carcinogen, they continue, raises questions about what the government response should be: “A coordinated and extensive search for SV40 in other kinds of tumours, coupled with far greater efforts to study how the virus causes tumours? A crash SV40 screening program among populations most likely to have been infected? … An anti-SV40 vaccination campaign?” The problem, they continue, is that to undertake any of these options the government would have to admit that it should have acted sooner to protect public health.

In The Structure of Scientific Revolutions (University of Chicago Press, 1962) Thomas Kuhn suggests that paradigm shifts don’t happen because opponents are converted by evidence, but rather because one generation of investigators and scientific leaders dies and is replaced by another. For credible epidemiological studies confirming whether SV40 from polio vaccines has caused human cancers, we may have to wait until a new generation is put in charge of the USA’s health research bureaucracy.