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COVID-19

Covid injections can cause kidney injury and renal damage

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In April 2023, an exhaustive review of the scientific literature relating to renal complications following covid vaccination was published in the Indian Journal of Community Medicine.

It described 28 mechanisms of kidney injury and renal damage from covid injections. There was a common theme of inflammation from cytokines and autoimmunity.


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Twenty-Eight Mechanisms of Kidney Injury with Covid-19 Vaccination

By Dr. Peter McCullough

I had a patient this year who presented far along the path of chronic kidney disease requiring initiation of renal replacement therapy otherwise known as dialysis. I wondered if covid-19 vaccination could injure the kidneys as it does the heart, brain, and so many other organs.

The kidneys receive about 25% of cardiac output and are continuously filtering the blood. Among the vaccinated, Brogna et al have shown about half of the vaccinated have detectable, full-length trimerised vaccine Spike protein in the bloodstream. It makes sense that both mRNA and Spike protein could settle in the kidney, cause expression of Spike protein and possibly other frameshifted peptide fragments on the cell surface of glomerular cells (renal epithelial, podocytes, mesangial) and because of the constant blood flow and urine exposure, product a hotspot for an immune attack against the organ.

A review by Vudathaneni et al described 28 published mechanisms of kidney injury and renal damage from covid-19 vaccination. Most of the pathways involve inflammation from either direct cytokine damage or auto-immunity.

Vudathaneni VKP, Nadella SB, Hema D, Boyapati R. Renal Complications Following COVID-19 Vaccination: A Narrative Literature Review. Indian J Community Med. 2023 Mar-Apr;48(2):214-219. doi: 10.4103/ijcm.ijcm_654_22. Epub 2023 Apr 7. PMID: 37323744; PMCID: PMC10263038.

The take-home message for doctors, nurses, and vaccinated patients is that renal function should be assessed with serum creatinine, cystatin-C, blood urea nitrogen, and urine albumin:creatinine ratio. If there is evidence of damage, then auto-immune markers including ANA, ANCA, RF, and anti-cyclic citrullinated peptide (anti-CCP) antibody should be drawn. Given the broad array of pathology, nephrologists should have a low threshold for renal biopsy so an accurate diagnosis can be made.

My fear is that with so many pressing medical problems including myocarditis, cardiac arrest, stroke, and blood clots, that renal damage may be overlooked and when the medical community and patients discover it, it may be too late to intervene.

About the Author

Peter A. McCullough is an American internist, cardiologist and epidemiologist.  He manages common infectious diseases as well as the cardiovascular complications of both the viral infection and the injuries developing after the covid vaccine in Dallas, Texas. 

Dr. McCullough has dozens of peer-reviewed publications on the infection and has commented extensively on the medical response to the covid crisis in The Hill, America Out Loud, and Fox News. Has testified multiple times in the US Senate, Texas Senate Committee on Health and Human Services, Arizona Senate and House of Representatives, Colorado General Assembly, New Hampshire Senate, Pennsylvania Senate and South Carolina Senate concerning many aspects of the pandemic response.

He has had years of dedicated academic and clinical efforts in combating the SARS-CoV-2 virus and in doing so has reviewed thousands of reports, participated in scientific congresses, group discussions and press releases, and has been considered among the world’s experts on covid.

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